Author profile
Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences
To establish an FMISO-PET–guided framework to estimate tumor control probability (TCP) and normal tissue complication probability (NTCP) in proton FLASH radiotherapy for efficacy prediction and clinical decision support.
This study evaluated the impact of interfractional rectal state changes on plan robustness in cervical cancer intensity-modulated proton therapy (IMPT) and established a robust optimization strategy incorporating multiple rectal conditions.
Radiotherapy has emerged as an effective noninvasive treatment for refractory ventricular tachycardia (VT). Given the high sensitivity of cardiac structures, proton therapy offers potential dosimetric advantages, but its robustness under cardiopulmonary motio...
To perform the first comprehensive dosimetric and radiobiological comparison of four modern delivery platforms for stereotactic body radiation therapy (SBRT) in pancreatic cancer: a conventional C-arm linac (TrueBeam), two established ring-gantry systems (Hal...
The combination of FLASH and ion-beam therapy could potentially enhance the therapeutic index of radiation therapy. The goal of this study was to establish a FLASH effect modeling approach for ion beams based on microdosimetry.
Severe radiation-induced lymphopenia (SRIL) is a detrimental prognostic factor in lung cancer. This study aimed to develop and validate normal tissue complication probability (NTCP) models for SRIL based on hematologic dose in patients receiving intensity-mod...
Spatially fractionated radiotherapy (SFRT) treats bulky tumors by creating heterogeneous dose distributions. Although both photon- and proton-based SFRT are accessible, various definitions of the peak-to-valley dose ratio (PVDR) may result in distinct dose di...
Hepatocellular carcinoma (HCC) treatment with intensity-modulated proton therapy (IMPT) is challenged by respiratory motion, necessitating 4D robust optimization. This study aimed to optimize the number of breathing phases required for 4D robust IMPT planning...
The Bragg peak of proton beam enables precise dose delivery and superior dose modulation in proton lattice radiotherapy (LRT), yet it remains susceptible to uncertainties. This study aims to investigate the impact of robust parameter settings and respiratory...