Author profile
Department of Radiation & Cellular Oncology, University of Chicago
Dose sparing of cardiac substructures has the potential to improve thoracic radiotherapy outcomes beyond conventional whole-heart dose-volume metrics. However, manual delineation of numerous substructures is prohibitive, limiting the availability of high-qual...
Multiparametric brain MRI is essential for delineating pediatric brain tumor subregions; however, long acquisition times often preclude complete multi-contrast imaging in pediatric patients, and large public pediatric lesion datasets remain limited. We propos...
Although immune checkpoint blockade (ICB) benefits only a subset of patients, combining ICB with stereotactic body radiation therapy (SBRT) may enhance therapeutic response. Building on a validated CT-based radiomics score (RS) that predicts patient-level res...
Therapy Physics
Accurate delineation of glioma substructures on multi-parametric MRI (mp-MRI) is critical for diagnosis, radiotherapy planning, and treatment response assessment. However, manual annotation of tumor subregions is labor-intensive and subject to inter-observer...
Gamma Knife (GK) radiosurgery is a specialized radiosurgery for brain metastases (BMs). GK plan quality depends strongly on target size and shape, making conventional plan metrics difficult to compare across patients. Dosimetric quality is also coupled with b...