Catherine Coolens, PhD

To predict achievable Gamma Knife (GK) radiosurgery plan quality and treatment time through analysis of geometric features from a large atlas of previously treated brain metastases.

Dynamic contrast enhanced CT (DCE-CT) is a functional imaging method used to measure vascular perfusion with high resolution and clinical value. DCE cone beam CT (DCE-CBCT) has been prevented by low image quality and lengthy acquisition, however, enhanced ima...

Tumor heterogeneity within and across tumors contributes to variable therapeutic response by altering biophysical transport barriers in the tumor microenvironment (TME). Elevated interstitial fluid pressure (IFP) and reduced hydraulic conductivity (K) generat...

To evaluate the feasibility and accuracy of a hyperspectral plastic scintillation detector (PSD) system (Medscint HYPERSCINT QA-200 with PRB-0019 probe)—commonly used for brachytherapy dosimetry—for Gamma Knife (GK) small-field dosimetry, and to quantify dete...

Biologically‑guided Adaptive Radiotherapy (BIGART) on clinical MR‑linac systems are increasingly enabled by quantitative MRI that can sense early biology, beyond conventional anatomy. This symposium spotlights innovation in quantitative MRI and their potentia...

To investigate the diagnostic performance of perfusion and diffusion MRI in differentiating progressing tumours from radiation necrosis in brain metastases (BM) post-radiosurgery, using a radiomic-based machine learning classification approach.