Gabriel O. Sawakuchi, PhD

To assess different proton beam arrangements’ robustness for planning stereotactic body proton therapy (SBPT) to the liver.

To assess the accuracy of empirical relative biological effectiveness (RBE) models in predicting variations in intrinsic radiosensitivity using a comprehensive dataset of clonogenic cell survival.

Radiotherapy is central in lung cancer treatment, but many tumors are intrinsically radioresistant. A mechanism of radioresistance in lung cancer is mutations in the KEAP1 gene, which is present in a significant number (15-20%) of lung cancers. This leads to...

To investigate the effects of combining proton and photon radiotherapy (RT) with a DNA polymerase theta inhibitor (Polθi) on DNA damage and promotion of tumor immunogenic remodeling.

Radiopharmaceutical therapy (RPT) is re-shaping how radiation is used to combat cancer since it provides a way to deliver radiation systemically. Due to its impactful clinical applications, RPT has been approved by the FDA to treat patients with metastatic ca...

High–linear energy transfer (LET) alpha-particle radiotherapy (RT) produces dense ionization tracks that generate complex DNA damage and may induce potent immunostimulatory signals. We compared alpha‑particle and photon RT across breast and pancreatic cancer...

To combat radioresistance by combining high linear energy transfer (LET) α-particles from diffusing alpha-emitters radiotherapy (Alpha-DaRT) with an inhibitor of ATR (Ataxia Telangiectasia and Rad3-related) (ATRi), a DNA repair protein that is involved in hom...

Recent advancements in x-ray optics have led to the development of a Bragg-reflecting x-ray lens to converge radiation beams into a focus spot (Convergent Radiotherapy and Radiosurgery, CRnR, Haifa, Israel), generating quasi-monoenergetic x-rays (~60 keV) wit...