Harald Paganetti, PhD

To develop tetrahedral mesh-based tissue models at the macro and micro-scale of the International Commission on Radiological Protection (ICRP) adult female mesh-type reference computational phantom (MRCP) breast inclusive of tissue-specific vasculature models...

To quantify the impact of proton dose calculation methodology, including nuclear halo contributions, on secondary cancer risk for near-field organs following proton craniospinal irradiation.

To quantify the effect of interfractional anatomic variation on dose-averaged linear energy transfer (LETd) in head-and-neck intensity-modulated proton therapy (IMPT), and to determine whether daily adaptive proton therapy (APT) further alters LETd compared w...

Current Y-90 radioembolization (RE) standard dosimetry assumes homogeneous microsphere distribution, ignoring patient-specific vasculature heterogeneity. We developed a framework to reproduce and augment patient-specific hepatic vascular models from cone-beam...

The NCI Pediatric Proton and Photon Therapy Comparison Cohort aims to compare the risk of second malignancies in patients treated with proton versus photon radiotherapy. Using Monte Carlo (MC) simulations, normal tissue dose estimates were retrospectively cal...

Iatrogenic cognitive deficits are a major concern in neuro-radiotherapy, especially in pediatric cases. Compared to X-ray treatment modalities, proton and ion beam therapies show improved sparing of cognitive functions, for which optimal neuronal dendritic br...

Clinical evidence generally suggests proton therapy can reduce treatment-related toxicity, especially in tumors near critical structures such as the brain, spinal cord, heart. This benefit is well established in pediatric cancers, where reducing radiation exp...

In the rapidly developing field of radiopharmaceuticals, the skeleton poses a uniquely daunting challenge to any effort to safely employ these powerful tools. The skeleton’s wide distribution throughout the body as well as its variability make dose difficult...