Author profile
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
To develop a slice-specific CT organ dose library using Monte Carlo radiation transport simulations on a set of newborn, infant, and toddler (NIT) computational phantoms containing newly developed age-specific skeletal tissue models. This dose library forms t...
To develop a library of 3D computational, tissue-representative models incorporating physiologically relevant microvascular network patterns for calculating local alpha particle and electron dosimetry effects. It is hypothesized that to compute scale-accurate...
To develop tetrahedral mesh-based tissue models at the macro and micro-scale of the International Commission on Radiological Protection (ICRP) adult female mesh-type reference computational phantom (MRCP) breast inclusive of tissue-specific vasculature models...
Congenital heart defects are the most common type of birth defect, and their management often requires lifelong medical care. Interventional cardiology procedures frequently rely on imaging modalities that use ionizing radiation, potentially exposing pediatri...
In the preclinical phase of radiopharmaceutical development, minipigs are frequently used to evaluate radiation-induced toxicity prior to human translation. Among normal organs, the kidney is a critical dose-limiting organ due to its roles in filtration, excr...
For radiopharmaceuticals emitting high linear energy transfer (LET) particles, such as alpha particles, the spleen can receive substantial localized doses due to its reticuloendothelial function. To capture dose heterogeneity, this study aims to develop three...
In prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy for metastatic castration-resistant prostate cancer, salivary glands often receive unintended high absorbed doses and are considered dose-limiting organs. For radiopharmaceutica...
To develop tetrahedral mesh-type phantoms of the female and male beagle dog and perform Monte Carlo (MC) radiation transport simulations to compute specific absorbed fractions (SAFs) for monoenergetic photons, electrons and alpha particles. These canine phant...
Current Y-90 radioembolization (RE) standard dosimetry assumes homogeneous microsphere distribution, ignoring patient-specific vasculature heterogeneity. We developed a framework to reproduce and augment patient-specific hepatic vascular models from cone-beam...
The Gamma-Emitter Contamination Assessment Tool (GECAT) is a software application designed to perform in-field radiological triage. The application relies on detector count rate efficiency data generated by performing Monte Carlo radiation transport on digita...
Following radiopharmaceutical administration, absorbed doses can be estimated by coupling radionuclide S values with cumulated activity. For alpha-emitting radiopharmaceuticals, S values should be established at a microscale level to account for heterogeneous...
In the rapidly developing field of radiopharmaceuticals, the skeleton poses a uniquely daunting challenge to any effort to safely employ these powerful tools. The skeleton’s wide distribution throughout the body as well as its variability make dose difficult...
The skeleton is of particular concern in radiation dosimetry, because it contains key target tissues for radiogenic cancers, including red bone marrow (RBM), associated with leukemia risk. However, skeletal dosimetry remains challenging due to the complex mic...
In preclinical studies, animal models are widely used to estimate absorbed doses following the administration of radiopharmaceuticals. Mice are the most commonly used models; however, their small body size can lead to biased dose estimates when translating mo...