Daniel A. Low, PhD

To quantify the precision and accuracy of a five-dimensional computed tomography (5DCT) free-breathing simulation approach in a large clinical cohort.

Dense lung vasculature landmarking is vital for assessing thoracic registration accuracy in treatment planning. We demonstrate an automated method for identifying vascular bifurcations in free-breathing CT images.

A CT-simulation approach has been developed which images free breathing patients with lung tumors by generating a motion model that is a function of breathing amplitude and rate (5DCT). Of the >300 patients simulated with 5DCT, 13 have been simulated more tha...

Functional avoidance radiotherapy requires accurate regional lung ventilation mapping. Jacobian-based free-breathing ventilation derived from deformable image registration (DIR) of 4DCT is established but susceptible to inaccuracies caused by errors in the di...

In investigating image-based lung ventilation, a fundamental question must be answered: is the measurement technique repeatable? Repeatability of ventilation imaging in PET and CT have been studied, but MRI is emerging. Crucial to deriving ventilation is the...

Standard Cone-Beam CT (CBCT) has limited utility in longitudinal lung tumor response assessment due to the presence of motion artifacts. Our proposed method of motion-compensated Simultaneous Algebraic Reconstruction Technique (mcSART) addresses these artifac...

4DCT is widely considered the standard for lung cancer radiation therapy treatment planning (TP) despite susceptibility to breathing-related motion artifacts that often render images unusable. Five-dimensional CT (5DCT), a model-based CT reconstruction method...

Recent advances in MRI could offer patients with benign lung disease whole-lung ventilation mapping that may serve as a surrogate for pathophysiological changes such as increased airway resistance and decreased lung compliance. Ventilation maps can be derived...

To test the feasibility of using lung hysteresis, or the difference in inhalation and exhalation motion trajectories, as a biomarker for mechanically affected lung.