Billy W Loo, MD, PhD

The significant tissue-sparing advantages of upright proton therapy (UPT) make it an appealing treatment for pediatric patients, yet its widespread use is limited by the lack of a commercially available solution for upright anesthesia-assisted treatment. Addi...

Clinical translation of FLASH requires treatment planning systems (TPS) capable of accurately modeling ultra-high dose rate delivery. For FLASH configurations on clinical machines, vendor-provided phase space files are not applicable, thus necessitating indiv...

Upright radiotherapy offers physiological and dosimetric advantages. Mevion S250-FIT, world’s first clinical ultra-compact synchrocyclotron-based upright proton therapy system, incorporates a novel upright CT for treatment planning and image guidance. This st...

Upright radiotherapy offers favorable physiological and geometric conditions compared with conventional supine delivery. However, posture-induced anatomical deformation complicates the alignment of supine diagnostic images with upright simulation and treatmen...

To characterize the reproducibility and dosimetric stability of a 5-day fractionated preclinical irradiation protocol delivered on a clinical Varian TrueBeam linac operated under FLASH and conventional (CONV) settings.

Radiation therapy optimization problems frequently involve multiple competing objectives, requiring multi-objective optimization to navigate trade-offs. This work used a Non-dominated Sorting Genetic Algorithm (NSGA-II) optimizer to identify Pareto-optimal ge...

Configuring clinical linear accelerators (LINACs) for ultra-high dose rate (UHDR) electron experiments typically requires invasive hardware modification or manufacturer intervention, limiting accessibility. We developed an independent, non-invasive, software-...

To quantify radiation induced glutathione (GSH) dynamics in A549 lung cancer cells using a ratiometric RealThiol (RT) probe and to assess microscopy and optical sensor platforms for real-time monitoring of redox responses following conventional and FLASH radi...

The Mevion S250-FIT is the world’s first ultra-compact proton therapy system designed with a form factor compatible with existing LINAC vaults. This raises questions regarding radiation shielding adequacy and electromagnetic compatibility with adjacent radiot...

To develop FAST-X to deliver ultra-high dose-rate (UHDR) irradiation for complex cranial targets.

Commissioning and performance validation of the world’s first ultra-compact upright proton therapy system and establish benchmarks for this novel treatment delivery paradigm.

Proton therapy offers superior dose conformity compared with photon therapy but remains limited by long delivery times and sensitivity to respiratory motion, particularly for thoracic tumors. Delivering an entire proton field within a short breath-hold (5–10s...

Current motion management systems are reactive: they detect patient displacement but require 200-400 ms to respond. This limitation prevents anticipatory intervention during breath-holds, forcing patients to their physiological limits before the system can re...