Michele M. Kim, PhD

The clinical translation of ultra-high dose rate (FLASH) radiotherapy is hindered by an incomplete understanding of the physical parameter space required to optimize normal tissue sparing. This study utilizes a human bone marrow-on-a-chip (BMoC) platform to m...

A proton conformal FLASH radiotherapy system was developed to generate spread-out Bragg peaks at tumor targets utilizing beam-modifying devices, consist of conformal energy modulator(CEM), range shifter(RS) and brass aperture(BA). The system delivers scanned...

Manual segmentation of immunohistochemical (IHC) stained images is a time-consuming task that typically takes 1-2 workdays to segment all images needed for analysis. Deep learning-based methods were employed to create an AI model to automatically segment IHC...

Radiation-induced damage to circulating lymphocytes is increasingly recognized as a critical determinant of both normal tissue toxicity and antitumor immune responses. Differences in radiation delivery time between proton conventional and FLASH dose rates may...

To design and validate a phantom capable of remote temporal and point dose rate assessment for electron and proton FLASH beams, with integrated spatial information to enable full end to end verification.

Therapy Physics