Serdar Charyyev

Prior to clinical launch of the world’s first installation of MEVION S250-FIT combined with Marie® system we evaluated anatomical and dosimetric differences between conventional photon-based supine treatments and proton-based upright treatments for prostate c...

The significant tissue-sparing advantages of upright proton therapy (UPT) make it an appealing treatment for pediatric patients, yet its widespread use is limited by the lack of a commercially available solution for upright anesthesia-assisted treatment. Addi...

The MEVION S250-FIT introduces a novel fixed-gantry, upright patient positioning system, yet lacks commercial secondary dose calculation (SDC) tools necessary for clinical safety verification. While Monte Carlo (MC) simulations offer gold-standard accuracy, t...

Precise proton therapy treatment planning relies on the synergy between the superior soft-tissue definition obtained from MRI and the accurate relative stopping power (RSP) maps derived from CT. However, standard workflows that utilize separate scans are ofte...

Clinical translation of FLASH requires treatment planning systems (TPS) capable of accurately modeling ultra-high dose rate delivery. For FLASH configurations on clinical machines, vendor-provided phase space files are not applicable, thus necessitating indiv...

Upright radiotherapy offers physiological and dosimetric advantages. Mevion S250-FIT, world’s first clinical ultra-compact synchrocyclotron-based upright proton therapy system, incorporates a novel upright CT for treatment planning and image guidance. This st...

Upright radiotherapy offers favorable physiological and geometric conditions compared with conventional supine delivery. However, posture-induced anatomical deformation complicates the alignment of supine diagnostic images with upright simulation and treatmen...

Overlapping tracks complicate particle classification and are unavoidable in pixelated semiconductor detectors due to their random nature. This study introduces a Hybrid Particle Track (HPT) net and a Simultaneous Track Energy And Length (STEAL) extension of...

The Mevion S250-FIT is the world’s first ultra-compact proton therapy system designed with a form factor compatible with existing LINAC vaults. This raises questions regarding radiation shielding adequacy and electromagnetic compatibility with adjacent radiot...

Commissioning and performance validation of the world’s first ultra-compact upright proton therapy system and establish benchmarks for this novel treatment delivery paradigm.

Proton therapy offers superior dose conformity compared with photon therapy but remains limited by long delivery times and sensitivity to respiratory motion, particularly for thoracic tumors. Delivering an entire proton field within a short breath-hold (5–10s...

Therapy Physics