Author profile
Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School
Cone beam CTs at typical kV energies exhibit metal artifacts in IGRT patients with metal prosthetics. MV-CBCT, available on some linacs, reduces artifacts at the expense of soft tissue contrast-to-noise (CNR). As a remedy, we propose an AI network to convert...
Preclinical studies combining radiation with gadolinium-based AGuIX nanoparticles show potent radiosensitization effect. However, physics simulations to date show a lack of macroscopic dose enhancement. We address this by shifting from absorbed dose (D) to mi...
During lung SBRT, tumor motion is managed using 4DCT-based ITV expansion, respiratory or external gating, or breath-hold techniques, each with limitations. Existing real-time tracking methods require implanted fiducials or additional imaging dose. A non-invas...
AGuIX nanoparticles, composed of a polysiloxane core with gadolinium chelates, are a theranostic agent, providing both MRI contrast and radiosensitization. The ongoing NanoBrainMets clinical trial looks to evaluate the therapeutic efficacy of AGuIX by quantif...
To evaluate the dosimetric accuracy of plans calculated on the Varian TrueBeam HyperSight cone beam CT (CTHS) imager upgrade compared to current fan beam simulation CT (CTSim) solutions towards online adaptive radiotherapy.
Conventional dual-energy material decomposition methods suffer from significant noise amplification, which limits their clinical utility for tasks such as intra-fraction markerless tumor tracking. This study introduces PRISM, an open-source Julia framework sp...
Dual-layer imagers (DLIs) enable simultaneous acquisition of low- and high-energy images in a single exposure, offering detector-based spectral imaging capability for the on-board kV imaging systems of conventional linear accelerators towards avoiding motion...
Spectral imaging confers several benefits such as material decomposition, increased soft tissue contrast, and metal artifact reduction. Novel methods currently under evaluation for adoption to linac onboard imaging include a kV dual-layer imager investigated...