Jufri Setianegara, PhD

This study aims to investigate the develop ultra-high-dose-rate (UHDR) proton FLASH spatially-fractionated-radiation-therapy (FLASH-SFRT) irradiations on a compact proton synchrocyclotron for preclinical experiments.

Carbon ion radiotherapy (CIRT) offers high LET and RBE for treating radioresistant tumors but suffers from biological dose inhomogeneity due to RBE uncertainties. Techniques like LET painting focus on optimizing LET but do not directly address biological effe...

A proton conformal FLASH radiotherapy system was developed to generate spread-out Bragg peaks at tumor targets utilizing beam-modifying devices, consist of conformal energy modulator(CEM), range shifter(RS) and brass aperture(BA). The system delivers scanned...

Therapy Physics

Proton minibeam radiation therapy (pMBRT) reduces normal tissue toxicity while preserving tumor control through spatial dose fractionation. However, multi-slit collimators (MSCs) substantially increase monitor unit requirements and delivery times, limiting cl...

On-board kV imaging systems on proton therapy machines predominantly rely on scintillator-based energy-integrating detectors (EIDs) for planar imaging and cone-beam CT (CBCT). However, EID-based CBCT is limited by suboptimal image quality and insufficient qua...

In this work, we experimentally commissioned proton spatially-fractionated-radiotherapy (pSFRT) clinical treatments on a compact proton synchrocyclotron. This involved an initial assessment of proton small-field dosimetry calculation accuracies with comprehen...

Radiation oncology is undergoing a transformative shift with the emergence of novel modalities that challenge traditional paradigms of dose delivery and biological response. This symposium will explore three cutting-edge approaches—Spatially Fractionated Radi...