Author profile
University of California, Irvine
Real-time dose verification remains a critical unmet need in radiation therapy. We developed physics-informed AI models for radiacoustic imaging (RAI) to enable quantitative, real-time in vivo dose monitoring for proton therapy. Our approach addresses two big...
Proton therapy is an increasingly adopted cancer treatment due to its high dose conformity enabled by the Bragg peak (BP), reducing radiation exposure to surrounding healthy tissue. However, this steep dose gradient makes treatment accuracy highly sensitive t...
Therapy Physics
Accurate radiotherapy delivery requires precise knowledge of soft-tissue anatomy at the time of treatment, particularly for abdominal targets affected by respiration, peristalsis, and inter-fractional anatomical changes. Current clinical systems provide limit...
Ultrafast ultrasound (UFUS) enables imaging of blood flow, functional dynamics, cardiac motion, and real-time treatment verification. UFUS is often acquired using high frame-rate single plane-wave imaging (SPWI), which has limited image quality due to the sin...
While Proton Acoustic (PA) imaging has shown promise for range verification, its application in complex transcranial environments remains under-explored. This study aims to demonstrate the feasibility of in situ 3D dose mapping and localization of pulsed prot...
Protoacoustic (PA) imaging enables real-time verification of proton dose deposition by reconstructing 3D initial pressure maps from acoustic signals generated during proton delivery. However, in practical treatment settings, detectors cannot fully surround th...
Therapy Physics
Upright patient positioning is transitioning rapidly from concept to clinic in both photon and proton therapy, supported by compact treatment systems, innovative immobilization devices, and the development of upright imaging platforms. Early studies highlight...