Author profile
Department of Radiation Oncology, University of Pennsylvania
Proton conformal FLASH radiotherapy must simultaneously satisfy clinical dosimetric goals and deliver ultra-high-dose-rates under machine constraints. This highly coupled optimization problem is currently addressed through manual trial-and-error, limiting pla...
Proton pencil-beam scanning (PBS) FLASH radiotherapy requires dosimetry systems capable of accurate and reliable operation under ultra high dose rate (UHDR) conditions. Faraday cups (FC) and multi-layer Faraday cups (MLFC) are dose-rate-independent charge col...
Radiation-induced damage to circulating lymphocytes is increasingly recognized as a critical determinant of both normal tissue toxicity and antitumor immune responses. Differences in radiation delivery time between proton conventional and FLASH dose rates may...