M. Ramish Ashraf

To evaluate the ability of a RefleXion X2 system with extended PET-FOV with a developmental Anchor Point Tracking algorithm to autonomously follow PET-avid target and deliver dose, accounting for large sudden target displacements.

Sparse detector arrays commonly used for patient-specific radiotherapy quality assurance (QA) cannot provide complete spatial dose distribution measurements, leading to uncertainties particularly in high-gradient dose regions.The goal of this project is to de...

Recent advances in nanophotonic engineering have enabled subwavelength nanostructures to be patterned onto conventional scintillating materials, significantly enhancing light yield by both amplifying and directing emission toward the detector. This study repr...

Clinical translation of FLASH requires treatment planning systems (TPS) capable of accurately modeling ultra-high dose rate delivery. For FLASH configurations on clinical machines, vendor-provided phase space files are not applicable, thus necessitating indiv...

The RefleXion X1 system requires activity concentration (AC) >5 kBq/mL for successful biology-guided radiotherapy (BgRT). We evaluated whether the extended field-of-view (FOV) PET detector in a can lower this AC threshold and expand treatment eligibility.

Configuring clinical linear accelerators (LINACs) for ultra-high dose rate (UHDR) electron experiments typically requires invasive hardware modification or manufacturer intervention, limiting accessibility. We developed an independent, non-invasive, software-...

To assess the effectiveness of a developmental anchor point tracking algorithm with PET deblurring in targeting tumors on the RefleXion X2 platform.

To examine the dose conformity during planning and delivery for complex C-shaped targets in an investigational RefleXion X2 platform under static and motion conditions.

Secondary electron range constrains standard 6MV radiotherapy to 80%-20% dose penumbra of ~2.4–3 mm, limiting conformity and organ sparing. Photon FLASH likely necessitates even larger penumbra, which is potentially problematic as the dose rates can be non-FL...

Current motion management systems are reactive: they detect patient displacement but require 200-400 ms to respond. This limitation prevents anticipatory intervention during breath-holds, forcing patients to their physiological limits before the system can re...

To evaluate the robustness of the developmental X2 Anchor Point Tracking algorithm to changes in breathing patterns between SCINTIX-modeling PET (for planning) and biology-guided radiation therapy (BgRT) treatment.