Proton prostate SBRT is characterized by steep dose gradients and elevated linear energy transfer (LET) near the end of range, which may contribute to genitourinary (GU) toxicity. Prior work suggests that bladder neck (trigone) dose is a stronger predictor of...
Author profile
Duncan Henry Bohannon, PhD
Department of Radiation Oncology and Winship Cancer Institute, Emory University
Pin-ridge filters (pRFs) have emerged as a promising hardware-based approach for ultrafast proton beam delivery through upstream proton fluence modulation. While pRF-based planning techniques having been explored computationally, experimental implementation h...
Radiation-induced lymphopenia (RIL) is a prevalent and clinically significant toxicity in lung cancer radiotherapy. Circulating lymphocyte exposure is inherently time-dependent due to blood flow through irradiated volumes during beam delivery. Intensity-modul...
Post-mastectomy chest-wall (CW) irradiation is well suited for proton FLASH due to the predominance of normal tissue within the target and the feasibility of single-energy tangential transmission beam (TB) delivery. This study investigates optimization strate...
Adaptive replanning in head and neck (H&N) radiotherapy can be resource-intensive and can also disrupt clinical workflow. We developed and validated a machine learning model that combines dosiomics and clinical features to predict which patients are likely to...