Author profile
University of Pennsylvania
Radiation-induced oral mucositis (OM) is a severe complication in head and neck cancer patients, significantly impacting quality of life. While Photobiomodulation (PBM) is a promising non-invasive management strategy, clinical protocols remain inconsistent re...
Cherenkov imaging enables non-invasive, real-time visualization of superficial dose during radiation therapy. In TSET using the Stanford standing technique, dose uniformity is highly sensitive to daily patient positioning. This study aims to experimentally de...
To refine the photochemical dose–response relationship for single-fraction Photofrin-mediated PDT by relating modeled reacted singlet oxygen dose to long-term tumor control and by using multispectral singlet oxygen luminescence detection (MSOLD) as an indepen...
This study develops an integrated framework combining three-dimensional deformable image registration with reactive oxygen species ([ROS]rx) modeling for comprehensive dosimetry in pleural photodynamic therapy (PDT). We aim to address clinical measurement gap...
Singlet oxygen (SO) is the primary cytotoxic agent in photodynamic therapy (PDT); however, real-time measurement of SO during treatment remains challenging. The purpose of this study is to investigate the dependence of SO signal on tissue oxygenation and trea...
Cherenkov imaging is a promising technique for visualizing and quantifying surface dose in radiation therapy. However, the absolute relationship between surface dose and emitted Cherenkov photons remains uncertain and varies with beam and tissue conditions. T...
Time-resolved singlet oxygen luminescence detection (TSOLD) enables direct measurement of singlet oxygen generation during photodynamic therapy (PDT), while multispectral SOLD (MSOLD) and singlet oxygen explicit dosimetry (SOED) provide complementary cumulati...
In Total Skin Electron Therapy (TSET) using the Stanford technique, the delivered dose is strongly affected by daily positioning uncertainties. This study presents an integrated framework that combines AI-assisted rapid generation of patient-specific six-post...
Cherenkov imaging has emerged as a promising technique for real-time dosimetry during external beam radiation therapy (EBRT); however, quantitative conversion of Cherenkov signal to delivered radiation dose remains challenging. The purpose of this study is to...