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Author profile
Youfang Lai, PhD
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University
A GPU-Based Computational Platform for Multi-Scale Modeling of Tumor Growth and Treatment Response In Lung Cancer Radiotherapy
Tumor growth and response to radiotherapy (RT) is a multiscale biological process encompassing cellular dynamics, extracellular transport, vascular and immune modeling. This work develops a comprehensive simulation platform to model this process with GPU acce...
Proffered Program · Therapy Physics
A Patient Quality Assurance System for Intensity Modulated Proton Therapy with Automated GPU-Accelerated Log File-Based Dose Reconstruction and Analysis In Under 10 Seconds
To develop and validate a log file-based patient quality assurance (LFQA) system for intensity modulated proton therapy (IMPT) using a GPU-accelerated pencil beam algorithm for dose reconstruction, permitting rapid log file upload, dose reconstruction, automa...
Poster Program · Therapy Physics
Automated Cyberknife Planning for Complex Central Nervous System Radiosurgery Using a Heuristic Optimization Framework
CyberKnife radiosurgery provides sub-millimeter targeting accuracy but relies on highly manual planning, often requiring several days and limiting throughput and consistency for time-sensitive cases. Currently, no commercial treatment planning system offers f...
Poster Program · Therapy Physics
Mechanistical Modeling of Radiation Response of Parotid In Head and Neck Cancer Radiotherapy
Radiotherapy (RT) for head and neck (HN) cancer frequently induces xerostomia due to radiation‑mediated parotid gland damage. Mechanistic modeling of parotid response may improve understanding of toxicity development and enable more biologically informed pred...
Poster Program · Therapy Physics
Radiation Chemistry–Based Characterization of Proton Beam Quality Using Hydroxyl Selective Fluorescence and Microscopic Monte Carlo Modeling
Proton beam quality varies with depth in both monoenergetic and spread-out Bragg peak (SOBP) beams due to changes in track structure and local energy deposition. This study investigates hydroxyl radical-sensitive fluorescence as an intrinsic method to quantif...
Poster Program · Therapy Physics
Beam Angle Optimization and Dose Quantification for Tumor Tracking Using Kv Scattered X-Ray Imaging
Photon-counting detectors (PCD) exhibit high sensitivity for scattered photons, enabling kilovoltage (kV) scattered X-ray imaging with potential for real-time tumor tracking for lung cancer radiotherapy. The performance in this application is strongly influen...
Proffered Program · Therapy Physics
Monte Carlo Simulation of a Novel Quantitative 177lu Imaging System Using a Photon-Counting Detector
Quantitative imaging of 177Lu radioactivity in radiopharmaceutical therapy is desired to capture its time-dependent biodistribution for dosimetry. We propose a novel imaging system using photon-counting detector (PCD) for high-sensitivity quantitative activit...
Proffered Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine
A GPU-Accelerated Monte Carlo Track-Structure Simulation Tool for Silicon Detectors
Track-structure Monte Carlo simulations are essential for modeling stochastic energy deposition at micro- and nanoscales relevant to radiobiology and for validating experiments in solid-state microdosimeters such as silicon-on-insulator (SOI) devices. However...
Proffered Program · Therapy Physics
Mechanistic Modeling of Radiation-Induced Plasmid DNA Damage Measured By Atomic Force Microscopy
Supercoiled plasmid DNA is widely used to study radiation-induced DNA damage. High-resolution atomic force microscopy (AFM) measurements of radiation-induced DNA fragment-length distributions have directly provided quantitative insights into radiation effects...
Proffered Program · Therapy Physics