Eric S. Diffenderfer, PhD

The clinical translation of ultra-high dose rate (FLASH) radiotherapy is hindered by an incomplete understanding of the physical parameter space required to optimize normal tissue sparing. This study utilizes a human bone marrow-on-a-chip (BMoC) platform to m...

Proton conformal FLASH radiotherapy must simultaneously satisfy clinical dosimetric goals and deliver ultra-high-dose-rates under machine constraints. This highly coupled optimization problem is currently addressed through manual trial-and-error, limiting pla...

Proton pencil-beam scanning (PBS) FLASH radiotherapy requires dosimetry systems capable of accurate and reliable operation under ultra high dose rate (UHDR) conditions. Faraday cups (FC) and multi-layer Faraday cups (MLFC) are dose-rate-independent charge col...

A proton conformal FLASH radiotherapy system was developed to generate spread-out Bragg peaks at tumor targets utilizing beam-modifying devices, consist of conformal energy modulator(CEM), range shifter(RS) and brass aperture(BA). The system delivers scanned...

Radiation-induced damage to circulating lymphocytes is increasingly recognized as a critical determinant of both normal tissue toxicity and antitumor immune responses. Differences in radiation delivery time between proton conventional and FLASH dose rates may...