Dante PI Capaldi, PhD, BS

As treatment planning evolves toward patient-specific optimization, traditional static dose constraints are insufficient for distinguishing high-quality versus acceptable plans. Current planning directives rely on generic dose constraints that fail to strive...

For medical physics residents, clinical decision-making can be a difficult skill to teach and master – most residents come from academic graduate programs with limited clinical exposure, and the regulatory nature of radiation oncology leads to limited opportu...

Cognitive decline following brain radiotherapy is strongly associated with hippocampal injury, yet scalable methods for assessing treatment-related hippocampal structural change in clinical practice remain limited. This study evaluates hippocampal volume loss...

Effective radiotherapy for upper abdominal tumors requires dose escalation but is limited by respiratory motion and the low gastrointestinal radiation tolerance. Current clinical motion management on conventional Linacs relies on simple external surrogates th...

In multi-target Gamma Knife (GK) radiosurgery, the clinical default plan typically sequences shots based on geometric efficiency to minimize treatment duration. However, this approach ignores the time-dependent biological effects of sublethal damage repair. T...

Cone-Beam CT (CBCT) is central to image-guided radiotherapy (IGRT), but conventional CBCT is limited in their ability to capture respiratory-induced tumor motion, resolve soft-tissue contrast, and account for anatomical changes during treatment. These limitat...

Current Gamma Knife (GK) planning typically decouples isocenter placement (heuristic-based) from sector duration optimization (SDO). This separation often leads to suboptimal plan quality and prolonged beam-on time (BOT). We propose an Integrated Isocenter an...