Matthew Stephen Andriotty, PhD

To evaluate dosimetric differences and dose calculation efficiency between the Anisotropic Analytical Algorithm (AAA) and Acuros XB for volumetric modulated arc therapy (VMAT)-based total body irradiation (TBI) planning.

To assess how different treatment planning techniques affect dose homogeneity and OAR sparing in VMAT total-body irradiation (TBI) plans.

To quantify the impact of interfractional variations on the dosimetric quality of VMAT TBI plans, primarily caused by potentially inconsistent upper limb placement at treatment; and to determine a clinically optimal setup for plan robustness against such vari...