Kristin Hsieh, MD

To investigate the role of interplay effects between respiratory motion and proton scanning beam interactions on free-breathing proton lattice radiotherapy (PLT) plans relative to dose distributions from static calculations.

Proton LATTICE radiotherapy (LRT), a spatially fractionated radiotherapy (SFRT), delivers high dose to intratumoral vertices while maintaining low valley dose. Single-field optimization (SFO) is robust in preserving peak-to-valley patterns but may increase en...

Ultra-high-dose-rate (UHDR) proton irradiation may spare normal tissue (FLASH effect), but PBS proton dose rate is limited by machine constraints (minimum MU/spot and dwell time). Intra-field interruptions can leave sub-threshold MU for remaining delivery, de...