Author profile
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
To investigate the effects of combining proton and photon radiotherapy (RT) with a DNA polymerase theta inhibitor (Polθi) on DNA damage and promotion of tumor immunogenic remodeling.
High–linear energy transfer (LET) alpha-particle radiotherapy (RT) produces dense ionization tracks that generate complex DNA damage and may induce potent immunostimulatory signals. We compared alpha‑particle and photon RT across breast and pancreatic cancer...
To combat radioresistance by combining high linear energy transfer (LET) α-particles from diffusing alpha-emitters radiotherapy (Alpha-DaRT) with an inhibitor of ATR (Ataxia Telangiectasia and Rad3-related) (ATRi), a DNA repair protein that is involved in hom...
Recent advancements in x-ray optics have led to the development of a Bragg-reflecting x-ray lens to converge radiation beams into a focus spot (Convergent Radiotherapy and Radiosurgery, CRnR, Haifa, Israel), generating quasi-monoenergetic x-rays (~60 keV) wit...