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Author profile
Max McLachlan, MS
University of Wisconsin-Madison School of Medicine and Public Health and Waisman Center
A Multimodal Study of Biomarkers of Alzheimer’s Disease In Adults with Down Syndrome: Diffusion Tensor Imaging and Tau-PET
Individuals with Down syndrome (DS) are at high risk of developing Alzheimer's Disease, partially driven by trisomy 21-related overproduction of amyloid precursor protein and plaque (Aβ) development. Tau neurofibrillary tangles typically follow Aβ and obey si...
Proffered Program · Diagnostic and Interventional Radiology Physics
BEST IN PHYSICS (RADIOPHARMACEUTICALS): Early Detection of Alzheimer’s Disease Tau Accumulation Measured with [¹⁸F]AV1451 PET at Low Levels of Amyloid Burden In Adults with Down Syndrome
Alzheimer’s disease (AD) progression can be monitored with longitudinal PET imaging. Changes in amyloid and tau; two characteristic AD proteins, are measured using [11C]PiB and [18F]AV1451, similar to how serial imaging with [18F]FDG is used to clinically ass...
Proffered Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine
Multi-Modal PET Imaging to Characterize the Relationship between Alzheimer’s Disease Pathology and Synaptic Density
Alzheimer’s disease (AD) is the most common form of dementia, exhibiting two characteristic brain neuropathologies - amyloid plaques (A) and neurofibrillary tau tangles (T) - hypothesized to disrupt neuronal function. Positron emission tomography (PET) is the...
Proffered Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine