Author profile
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center
Dose–volume metrics alone incompletely explains mandibular osteoradionecrosis (ORN) following proton therapy. LET-based aggregate approaches such as dose–LET volume histograms (DLVH) implicitly assume uniform LET contribution across dose levels. This study in...
While 30% of lung cancer patients cannot tolerate breath-hold, free-breathing(FB) proton pencil-beam-scanning(PBS) deliveries compromise target coverage from the interplay effects of large motion. This study presents a novel FB-gated spirometer-based respirat...
Tumor hypoxia drives radio-resistance in Head & Neck cancer (HNC) and can guide radiation dose de-escalation. Tumor hypoxia can be imaged using 18F-fluoromisonidazole (FMISO-PET; non-standard-of-care). Because hypoxia drives glycolysis, we assessed correlatio...
Linear energy transfer (LETd) has been implicated in mandibular osteoradionecrosis (ORN) following proton therapy; however, its strong spatial coupling with dose has limited interpretation of whether LETd contributes independently to ORN risk. This study aims...