Quantitative Autoradiography-Based Stochastic Microscale Dosimetry for α-Emitter Radiopharmaceutical Therapy
Mean absorbed dose is commonly used to interpret radiopharmaceutical therapy outcomes. For α-emitter radiopharmaceutical therapy (αRPT), however, energy deposition is stochastic at the cellular scale, while tissue-level Monte Carlo-based microdosimetry is com...
Proffered Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine
BEST IN PHYSICS (RADIOPHARMACEUTICALS): Quantitative Decay-Chain-Resolved Autoradiography Enables Microscale Assessment of ²²⁵Ac Daughter Redistribution In Tissue
Redistribution of radioactive daughters following ²²⁵Ac decay is a major dose-limiting uncertainty in α-emitter radiopharmaceutical therapy (αRPT). Free daughter species may diffuse from their site of origin, yet their microscale fate within tissue remains po...
Proffered Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine