Author profile
University of Wisconsin-Madison Department of Human Oncology
To develop and validate a 3D deep learning autosegmentation model for prostate and OAR contouring on post-brachytherapy-catheter CT images for HDR prostate brachytherapy planning.
Radiopharmaceutical therapy (RPT) delivers targeted radiation to cancer cells. Patient‑specific dosimetry can help estimate dose and predict treatment outcome. However, tumor segmentation approaches vary across institutions, introducing uncertainty into dose...
Catheter position uncertainty produces dosimetric error in HDR prostate brachytherapy, with reported displacements between planning and delivery of up to 5-7mm. Current inverse planning methods optimize dwell times for fixed catheter positions without account...
Focal dose escalation to the dominant intraprostatic lesion (GTV) improves biochemical control but is limited by urethral toxicity. 177Lu-PSMA radiopharmaceutical therapy (RPT) offers a targeted boost, yet its spatial heterogeneity in uptake leaves GTV sub-re...