James Fowler

Accurate 177Lu SPECT quantification is essential for patient-specific dosimetry in radiopharmaceutical therapies. Monte Carlo (MC) based reconstruction uses comprehensive system modeling to stochastically simulate photon transport and detector interactions, p...

Physiologically based pharmacokinetic (PBPK) models used in radiopharmaceutical therapy (RPT) and theranostic digital twins are rapidly increasing in size and mechanistic detail, often containing tens to hundreds of parameters. While such models fit imaging a...

Radiopharmaceutical therapies (RPTs) effectively treat metastatic castration-resistant prostate cancer, yet injected radioactivities remain empirically prescribed. Although physiologically-based pharmacokinetic (PBPK) and pharmacodynamic (PD) models can separ...

Existing "one-size-fits-all" approaches in PSMA radiopharmaceutical therapies (RPTs) fail to account for critical inter-patient variabilities, risking under- or over-treatment. To address this, we are developing theranostic digital twins (TDTs) for reliable p...

Computational nuclear oncology (CNO) methods are advancing rapidly but often developed in isolated tools and workflows that are difficult to reproduce, compare, and share. This fragmentation limits virtual studies and slows translation of physiologically base...

Theranostic digital twins (TDTs) are virtual representations of individual patients, that integrate clinical patient history, imaging, and physiologically based pharmacokinetic (PBPK) modeling to simulate radiopharmaceutical therapies (RPTs). Their validation...

Accurate quantitative assessment in positron emission tomography (PET) is essential for reliable lesion characterization and therapy response evaluation. Quantitative accuracy is conventionally investigated using physical phantoms or numerical simulations; ho...