Sean J. Domal

Direct-to-Unit (simulation-omitted) radiotherapy enables treatment planning directly from diagnostic imaging, eliminating CT simulation and supporting same-day treatment for time-sensitive cases. These workflows rely on adaptive radiotherapy (ART) platforms t...

Magnetic resonance imaging-guided online adaptive radiotherapy (MRgRT) requires a complex planning process, during which an upstream peer review prior to physician approval plays an essential role in early error detection and supporting safe and efficient onl...

Lattice radiotherapy (LATTICE) is a spatially fractionated technique that delivers high doses to discrete peak regions within the target while maintaining lower doses in surrounding valley regions, yielding a high peak-to-valley dose ratio (PVDR). Conventiona...

To compare MR-simulation motion emulation with measured respiratory gating performance for ultra-central lung treatments on 1.5T MR-linac and to identify the dominant factors affecting gating efficiency. The study focuses on the role of tracking surrogate sel...

To develop and validate consensus electron density (ED) look-up tables (LUTs) for MR-only radiotherapy planning through multi-institutional collaboration.

Lattice stereotactic body radiation therapy (Lattice SBRT) delivers spatially fractionated high-dose vertices embedded within a lower-dose tumor base, producing steep dose gradients potentially sensitive to interfractional anatomical change. This study evalua...

to evaluate performance of Elekta Unity 1.5T MR-Linac Comprehensive Motion Management (CMM) system across multiple gating strategies and anatomical sites: gastrointestinal(GI), genitourinary(GU), and thoracic(lung). This work aims to provide a practical refer...

Direct-to-treatment radiotherapy eliminates CT simulation and pre-planning, reduces consultation-to-treatment intervals from weeks to hours. This study evaluated the feasibility of an ultra-hypofractionated whole-breast workflow that omits simulation and adva...

Radiation therapy(RT) planning remains a manual, trial-and-error process that consumes significant clinical time and yields inconsistent results. We present a compound AI platform integrated with a commercial treatment-planning-system(TPS), combining autonomo...

Direct-to-unit (DTU) radiotherapy, which bypasses CT simulation and prospective planning, offers an opportunity to markedly shorten the interval from consultation to treatment and expand access to timely breast cancer care. Building on prior feasibility work,...

Therapy Physics