Alan Lee, MD

To quantify the precision and accuracy of a five-dimensional computed tomography (5DCT) free-breathing simulation approach in a large clinical cohort.

Large, well-annotated databases are necessary for the development of personalized outcomes models. We evaluated the viability of using a Large Language Model (LLM) to extract patient-specific specific toxicity and progression outcomes from unstructured radiol...

A CT-simulation approach has been developed which images free breathing patients with lung tumors by generating a motion model that is a function of breathing amplitude and rate (5DCT). Of the >300 patients simulated with 5DCT, 13 have been simulated more tha...

MRI-guided lung SBRT has emerged as a novel treatment modality with the potential to enhance motion management and improve normal lung sparing. This retrospective study evaluates the extent of normal lung sparing achieved by real-time tracking and automatic g...

In investigating image-based lung ventilation, a fundamental question must be answered: is the measurement technique repeatable? Repeatability of ventilation imaging in PET and CT have been studied, but MRI is emerging. Crucial to deriving ventilation is the...

4DCT is widely considered the standard for lung cancer radiation therapy treatment planning (TP) despite susceptibility to breathing-related motion artifacts that often render images unusable. Five-dimensional CT (5DCT), a model-based CT reconstruction method...

Recent advances in MRI could offer patients with benign lung disease whole-lung ventilation mapping that may serve as a surrogate for pathophysiological changes such as increased airway resistance and decreased lung compliance. Ventilation maps can be derived...

To test the feasibility of using lung hysteresis, or the difference in inhalation and exhalation motion trajectories, as a biomarker for mechanically affected lung.