Lawrie Skinner, PhD

The significant tissue-sparing advantages of upright proton therapy (UPT) make it an appealing treatment for pediatric patients, yet its widespread use is limited by the lack of a commercially available solution for upright anesthesia-assisted treatment. Addi...

Precise proton therapy treatment planning relies on the synergy between the superior soft-tissue definition obtained from MRI and the accurate relative stopping power (RSP) maps derived from CT. However, standard workflows that utilize separate scans are ofte...

Clinical translation of FLASH requires treatment planning systems (TPS) capable of accurately modeling ultra-high dose rate delivery. For FLASH configurations on clinical machines, vendor-provided phase space files are not applicable, thus necessitating indiv...

To characterize the reproducibility and dosimetric stability of a 5-day fractionated preclinical irradiation protocol delivered on a clinical Varian TrueBeam linac operated under FLASH and conventional (CONV) settings.

Configuring clinical linear accelerators (LINACs) for ultra-high dose rate (UHDR) electron experiments typically requires invasive hardware modification or manufacturer intervention, limiting accessibility. We developed an independent, non-invasive, software-...

The Mevion S250-FIT is the world’s first ultra-compact proton therapy system designed with a form factor compatible with existing LINAC vaults. This raises questions regarding radiation shielding adequacy and electromagnetic compatibility with adjacent radiot...

To develop and characterize a lost-cost, 3D-printed, patient-specific electron cutout filled with steel ball bearings (BBs) for use with Elekta linear accelerators, and to assess current electron radiotherapy (ERT) practices and clinical perspectives on exist...

Total Skin Electron Irradiation (TSEI) is traditionally delivered with the patient standing at an extended source-to-surface distance, a position often intolerable for frail or compromised patients. While floor-based recumbent alternatives exist, they necessi...

Commissioning and performance validation of the world’s first ultra-compact upright proton therapy system and establish benchmarks for this novel treatment delivery paradigm.

To develop and evaluate a simulation-free, single-visit workflow for MRI-guided stereotactic ablative radiotherapy (SABR) for liver tumors using on-table imaging and online adaptive replanning, and to validate an MR-only dose calculation approach based on bul...

Secondary electron range constrains standard 6MV radiotherapy to 80%-20% dose penumbra of ~2.4–3 mm, limiting conformity and organ sparing. Photon FLASH likely necessitates even larger penumbra, which is potentially problematic as the dose rates can be non-FL...

Collision risk between the patient/immobilization devices with gantry or the on-board imaging system remains a safety and workflow concern in modern radiotherapy. We built and implemented a real-time laser visualization system, enabling immediate assessment o...