Author profile
Department of Radiation Oncology, University of Kansas Medical Center
Beam angle optimization (BAO) is a critical component of radiation therapy (RT) treatment planning, particularly for proton therapy, where small variations in beam configuration can substantially affect plan quality. BAO is naturally formulated as a mixed-int...
Proton LATTICE (pLATTICE) therapy delivers spatially heterogeneous dose distributions with high‑dose peaks embedded within low‑dose valleys. Conventional pLATTICE planning typically uses multiple beam angles per peak, making peak localization vulnerable to pr...
Lattice radiotherapy (LATTICE) is a spatially fractionated technique that delivers high doses to discrete peak regions within the target while maintaining lower doses in surrounding valley regions, yielding a high peak-to-valley dose ratio (PVDR). Conventiona...
Lattice radiotherapy (LRT) is a spatially fractionated radiation technique that creates three-dimensional arrays of high-dose vertices within tumor volumes. Current LRT implementations face geometric constraints in small and medium-sized tumors, primarily due...
Proton minibeam radiation therapy (pMBRT) employs spatially fractionated dose distributions to improve the therapeutic index by reducing normal tissue toxicity. A key component of pMBRT is multi-slit collimator (MSC), which shapes the beam into narrow, spatia...