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Department of Radiation Oncology, National Cancer Center Hospital
The tumor-to-normal ratio of maximum uptake (Tmax/N) on 18F-BPA PET is widely used to guide decision-making regarding boron neutron capture therapy (BNCT). However, intratumoral heterogeneity of boron drug distribution may also influence clinical outcomes. Th...
In BNCT, 18F-BPA-PET evaluates boron drug distribution for treatment eligibility, but is rarely incorporated into treatment planning. A key limitation is differences in drug administration protocols between PET and BNCT, which may weaken clinical outcome-to-d...
Accelerator-based boron neutron capture therapy (BNCT) system employing a solid-state lithium target has been implemented into clinical practices. However, due to the degradation of the Li target over its lifetime, periodic replacement is necessary. This stud...