Devika Chithrani, PhD

Gold nanoparticles (GNPs) are promising radiosensitizing agents for high dose rate brachytherapy (HDR); however, complex treatment delivery for HDR has prohibited systematic evaluation of GNP-induced radiosensitization both in vitro and in vivo. Here, we use...

Gold nanoparticles (GNPs) are candidate cancer cell radiosensitizers, they can be targeted with peptides containing the αvβ3 integrin binding domain RGD (arginine, glycine, aspartic acid). This integrin is overexpressed in many cancer cells. Peptide shape-bas...

The integration of radiosensitizing chemotherapeutics with radiotherapy represents a promising strategy to enhance tumor response. However, conventional systemic administration often results in limited tumor drug delivery, reducing radiosensitization while in...

Radiotherapy with a 6 MV linear accelerator is extensively employed in cancer treatment, particularly for targeting deep-seated tumors. In our work, we have focused on maximizing the dose that can be safely delivered to patients. Our primarygoal is to optimiz...

To investigate the synergistic radiosensitization of gold nanoparticles (GNPs) and paclitaxel (PTX) in high dose-rate (HDR) brachytherapy for prostate cancer using 2D (monolayer) and 3D (spheroid) cell models. HDR is used as a localized boost following extern...