Author profile
Duke University
Standardizing the assessment of the Tumor Microenvironment (TME) is critical for personalizing therapy in Head and Neck Squamous Cell Carcinoma (HNSCC). As part of a larger multiomics effort to discover multiscale biomarkers, we developed a mathematical frame...
Understanding chemoradiation resistance remains a major barrier to improving outcomes in head and neck cancer. We developed a multiscale framework linking tumor architecture, cellular network topology, and immune context to therapeutic response. This approach...
Head and neck squamous cell carcinoma (HNSCC) is a clinically aggressive malignancy with heterogeneous responses to chemoradiation, driven in part by dynamic immune remodeling. While immune infiltration has been studied at different time points, the spatiotem...
Murine models of head and neck squamous cell carcinoma (HNSCC) are routinely monitored using external caliper measurements to estimate tumor volume, most often relying on simplified geometric assumptions such as cylindrical approximations. While convenient, t...