Matthew Jonathan Muscat, MS

To develop a Gaussian process regression (GPR) framework that treats along-core HDR prostate brachytherapy dose as a spatially correlated signal, in order to denoise voxel-level dose and dose-uncertainty summaries used for Monte Carlo biopsy dose quality assu...

To perform cohort-level probabilistic quality assurance of biopsy dose thresholds in HDR prostate brachytherapy under a fixed localization-uncertainty model and relate robustness to nominal distance from threshold.

To quantify the dosimetric impact of transitioning from water-based TG-43 dose evaluations to advanced model-based TG-186 calculations in permanent prostate brachytherapy, and to assess the effects on target coverage, organ-at-risk doses, and the appropriaten...