Makoto Shinoto, MD, PhD

To establish the treatment planning protocol and evaluate the biological rationale for the world’s first dose-averaged LET (LETd)-optimized multi-ion therapy program for head and neck cancers. This study characterizes the plan robustness and potential therape...

Tumor oxygenation plays a critical role in treatment response and progression. However, repeating PET with hypoxia-specific radioligands at every treatment fraction is not practical. Tumor-vascular status, by contrast, can be assessed by measuring the washout...