Stephen L. Brown, PhD

Dynamic contrast-enhanced (DCE)-MRI is widely used to assess vascular perfusion and permeability; however, conventional time-domain pharmacokinetic models often conflate flow- and leakage-driven transport. This study introduces a Laplace-domain framework to q...

Dynamic-contrast–enhanced (DCE) MRI enables quantitative assessment of microvascular permeability but is constrained at low field by reduced SNR and ambiguous voxel-wise model selection. This study constructs and evaluates an unsupervised probabilistic-nested...