Irini Yacoub, MD

To investigate the role of interplay effects between respiratory motion and proton scanning beam interactions on free-breathing proton lattice radiotherapy (PLT) plans relative to dose distributions from static calculations.

While 30% of lung cancer patients cannot tolerate breath-hold, free-breathing(FB) proton pencil-beam-scanning(PBS) deliveries compromise target coverage from the interplay effects of large motion. This study presents a novel FB-gated spirometer-based respirat...

Proton LATTICE radiotherapy (LRT), a spatially fractionated radiotherapy (SFRT), delivers high dose to intratumoral vertices while maintaining low valley dose. Single-field optimization (SFO) is robust in preserving peak-to-valley patterns but may increase en...

Ultra-high-dose-rate (UHDR) proton irradiation may spare normal tissue (FLASH effect), but PBS proton dose rate is limited by machine constraints (minimum MU/spot and dwell time). Intra-field interruptions can leave sub-threshold MU for remaining delivery, de...

With the number of proton centers increasing, each facing intermittent downtime or need for renovations. Developing optimal approaches to maintain uninterrupted treatment is essential to preserve clinical outcomes. This study outlines key risk factors, workfl...