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New York Proton Center
Dose-averaged linear energy transfer (LETd) is increasingly used to characterize biological risk in proton therapy. However, LET definitions differ among treatment planning systems. RayStation 2023B reports LET-to-water, whereas Monte Carlo engines such as MC...
Dose–volume metrics alone incompletely explains mandibular osteoradionecrosis (ORN) following proton therapy. LET-based aggregate approaches such as dose–LET volume histograms (DLVH) implicitly assume uniform LET contribution across dose levels. This study in...
Proton LATTICE radiotherapy (LRT), a spatially fractionated radiotherapy (SFRT), delivers high dose to intratumoral vertices while maintaining low valley dose. Single-field optimization (SFO) is robust in preserving peak-to-valley patterns but may increase en...
Linear energy transfer (LETd) has been implicated in mandibular osteoradionecrosis (ORN) following proton therapy; however, its strong spatial coupling with dose has limited interpretation of whether LETd contributes independently to ORN risk. This study aims...