Author profile
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
In the preclinical phase of radiopharmaceutical development, minipigs are frequently used to evaluate radiation-induced toxicity prior to human translation. Among normal organs, the kidney is a critical dose-limiting organ due to its roles in filtration, excr...
For radiopharmaceuticals emitting high linear energy transfer (LET) particles, such as alpha particles, the spleen can receive substantial localized doses due to its reticuloendothelial function. To capture dose heterogeneity, this study aims to develop three...
In prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy for metastatic castration-resistant prostate cancer, salivary glands often receive unintended high absorbed doses and are considered dose-limiting organs. For radiopharmaceutica...
To develop tetrahedral mesh-type phantoms of the female and male beagle dog and perform Monte Carlo (MC) radiation transport simulations to compute specific absorbed fractions (SAFs) for monoenergetic photons, electrons and alpha particles. These canine phant...
Following radiopharmaceutical administration, absorbed doses can be estimated by coupling radionuclide S values with cumulated activity. For alpha-emitting radiopharmaceuticals, S values should be established at a microscale level to account for heterogeneous...
The skeleton is of particular concern in radiation dosimetry, because it contains key target tissues for radiogenic cancers, including red bone marrow (RBM), associated with leukemia risk. However, skeletal dosimetry remains challenging due to the complex mic...
In preclinical studies, animal models are widely used to estimate absorbed doses following the administration of radiopharmaceuticals. Mice are the most commonly used models; however, their small body size can lead to biased dose estimates when translating mo...