Author profile
Department of Human Oncology, University of Wisconsin-Madison
The spread-out Bragg peak (SOBP) technique uses ridge filters to broaden the depth-dose profile, producing a dose distribution similar to a single-field-uniform(SFU) approach. In contrast, the single-energy pristine Bragg peak(SEPBP) approach relies on range...
We report the first clinical implementation integrating a 6D upright treatment chair and a vertical CT system for image-guided proton therapy on a synchrotron-based fixed-beamline. This design aims to improve patient workflow and reduce the facility footprint...
Hypofractionated proton therapy for pancreatic cancer is limited by the proximity of radiosensitive abdominal organs. Single-energy Bragg peak (SEBP) proton delivery enables ultra-high dose-rate (UHDR) irradiation and may facilitate FLASH compatible treatment...
Intensity-modulated proton therapy (IMPT) plan optimization is time-intensive due to its high dimensionality and the inherent non-convexity of clinical dosimetric constraints. Conventional algorithms like projected gradient descent (PGD) often require extensi...