Author profile
Duke University
Standardizing the assessment of the Tumor Microenvironment (TME) is critical for personalizing therapy in Head and Neck Squamous Cell Carcinoma (HNSCC). As part of a larger multiomics effort to discover multiscale biomarkers, we developed a mathematical frame...
Understanding chemoradiation resistance remains a major barrier to improving outcomes in head and neck cancer. We developed a multiscale framework linking tumor architecture, cellular network topology, and immune context to therapeutic response. This approach...
Personalized oncology requires bridging the gap between macro-scale imaging and micro-scale cellular architecture. We developed a radiopathomic fusion framework to integrate PET/CT metabolic heterogeneity with graph-based topological modeling of the tumor mic...
Head and neck squamous cell carcinoma (HNSCC) is a clinically aggressive malignancy with heterogeneous responses to chemoradiation, driven in part by dynamic immune remodeling. While immune infiltration has been studied at different time points, the spatiotem...
To investigate mechanisms of chemoradiation resistance in murine head and neck squamous cell carcinoma using a multiscale framework integrating metabolic imaging (μPET), tissue heterogeneity (μCT), and cellular topology (digital pathology).