Author profile
Department of Human Oncology, University of Wisconsin-Madison
We report the first clinical implementation integrating a 6D upright treatment chair and a vertical CT system for image-guided proton therapy on a synchrotron-based fixed-beamline. This design aims to improve patient workflow and reduce the facility footprint...
Hypofractionated proton therapy for pancreatic cancer is limited by the proximity of radiosensitive abdominal organs. Single-energy Bragg peak (SEBP) proton delivery enables ultra-high dose-rate (UHDR) irradiation and may facilitate FLASH compatible treatment...
To implement a full abdominal motion model that combines respiration with gastrointestinal (GI) motility and quantify its interplay impact in pencil-beam scanning (PBS) proton therapy.
Proton LATTICE radiotherapy (LRT), a spatially fractionated radiotherapy (SFRT), delivers high dose to intratumoral vertices while maintaining low valley dose. Single-field optimization (SFO) is robust in preserving peak-to-valley patterns but may increase en...
Ultra-high-dose-rate (UHDR) proton irradiation may spare normal tissue (FLASH effect), but PBS proton dose rate is limited by machine constraints (minimum MU/spot and dwell time). Intra-field interruptions can leave sub-threshold MU for remaining delivery, de...
Respiratory-induced interplay effects in spot-scanning proton therapy can lead to dose degradation for lung cancer patients treated under free-breathing conditions. While motion mitigation techniques such as deep-inspiration breath-hold or abdominal compressi...
Adaptive radiation therapy (ART) for proton therapy relies on routine offline CT simulations for updated anatomy. To facilitate online proton ART, we present our high‑fidelity regularized Brownian Bridge (rBBrg) framework to perform deterministic cross-modali...
Intensity-modulated proton therapy (IMPT) plan optimization is time-intensive due to its high dimensionality and the inherent non-convexity of clinical dosimetric constraints. Conventional algorithms like projected gradient descent (PGD) often require extensi...
To quantify the impact of gastrointestinal (GI) motility on pencil-beam scanning (PBS) proton therapy for abdominal cancers, and assess how fractionation and motion amplitude mitigate motility-induced interplay effects.