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Author profile
Ioannis I. Verginadis, PhD
Department of Radiation Oncology, University of Pennsylvania
High-Throughput Interrogation of the Human Hematopoietic Response to Proton Pbs Flash Radiotherapy Using a Bone Marrow-on-a-Chip Platform
The clinical translation of ultra-high dose rate (FLASH) radiotherapy is hindered by an incomplete understanding of the physical parameter space required to optimize normal tissue sparing. This study utilizes a human bone marrow-on-a-chip (BMoC) platform to m...
Proffered Program · Therapy Physics
Development of an AI Method for Rapid Immunohistochemical Stained Image Structure Auto-Segmentation
Manual segmentation of immunohistochemical (IHC) stained images is a time-consuming task that typically takes 1-2 workdays to segment all images needed for analysis. Deep learning-based methods were employed to create an AI model to automatically segment IHC...
Poster Program · Therapy Physics
BEST IN PHYSICS (THERAPY): Simulation of Dose-Rate Dependent Mechanisms of Lymphocyte Damage In Proton Flash Radiotherapy
Radiation-induced damage to circulating lymphocytes is increasingly recognized as a critical determinant of both normal tissue toxicity and antitumor immune responses. Differences in radiation delivery time between proton conventional and FLASH dose rates may...
Proffered Program · Therapy Physics