Author profile
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine
Tumor growth and response to radiotherapy (RT) is a multiscale biological process encompassing cellular dynamics, extracellular transport, vascular and immune modeling. This work develops a comprehensive simulation platform to model this process with GPU acce...
To implement a full abdominal motion model that combines respiration with gastrointestinal (GI) motility and quantify its interplay impact in pencil-beam scanning (PBS) proton therapy.
Radiotherapy (RT) for head and neck (HN) cancer frequently induces xerostomia due to radiation‑mediated parotid gland damage. Mechanistic modeling of parotid response may improve understanding of toxicity development and enable more biologically informed pred...
Respiratory-induced interplay effects in spot-scanning proton therapy can lead to dose degradation for lung cancer patients treated under free-breathing conditions. While motion mitigation techniques such as deep-inspiration breath-hold or abdominal compressi...
To quantify the impact of gastrointestinal (GI) motility on pencil-beam scanning (PBS) proton therapy for abdominal cancers, and assess how fractionation and motion amplitude mitigate motility-induced interplay effects.