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Author profile
Poliana Marinello
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center
Polθ Inhibition Enhances Proton and Photon Radiotherapy By Increasing DNA Damage and Tumor Immunogenic Remodeling
To investigate the effects of combining proton and photon radiotherapy (RT) with a DNA polymerase theta inhibitor (Polθi) on DNA damage and promotion of tumor immunogenic remodeling.
Proffered Program · Therapy Physics
High-LET Alpha Particle Radiation Enhances the Potential of Tumor Cells to Activate an Anti-Tumor Immune Response Compared with Photons
High–linear energy transfer (LET) alpha-particle radiotherapy (RT) produces dense ionization tracks that generate complex DNA damage and may induce potent immunostimulatory signals. We compared alpha‑particle and photon RT across breast and pancreatic cancer...
Proffered Program · Therapy Physics
Synergistically Overcoming Tumor Radioresistance By Combining High-LET α-Particle Radiotherapy with ATR Inhibition
To combat radioresistance by combining high linear energy transfer (LET) α-particles from diffusing alpha-emitters radiotherapy (Alpha-DaRT) with an inhibitor of ATR (Ataxia Telangiectasia and Rad3-related) (ATRi), a DNA repair protein that is involved in hom...
Proffered Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine