To quantify the effect of interfractional anatomic variation on dose-averaged linear energy transfer (LETd) in head-and-neck intensity-modulated proton therapy (IMPT), and to determine whether daily adaptive proton therapy (APT) further alters LETd compared w...
Author profile
Antony John Lomax, PhD
Paul Scherrer Institute
Impact of Online Adaptive Proton Therapy on Linear Energy Transfer In Head-and-Neck Cancer Under Daily Anatomic Variation
Poster Program · Therapy Physics
Synthetic CT Generation from Cone-Beam CT for Online Adaptive Radiotherapy Using Flow Matching and Diffusion Schrödinger Models
Synthetic CT (sCT) generation from cone-beam CT (CBCT) enables accurate online adaptive radiotherapy, to account for daily anatomical and positioning variability in radiotherapy. We introduce two models for CBCT-to-sCT generation: to the best of our knowledge...
Poster Program · Therapy Physics
Uncertainty Quantification In Neural Network-Based Proton Pencil Beam Dose Prediction
Deep learning-based dose prediction has emerged as a transformative approach for rapid radiotherapy planning. However, these models typically operate as "black boxes," providing only deterministic predictions without quantifying output reliability. This lack...
Proffered Program · Therapy Physics