Charles B. Simone, MD

Traditional patient-specific QA in proton therapy requires detector-based measurements that consume beam time and delay workflow. This study presents a calibration-based machine log analysis system enabling automated, measurement-free verification of delivere...

Dose-averaged linear energy transfer (LETd) is increasingly used to characterize biological risk in proton therapy. However, LET definitions differ among treatment planning systems. RayStation 2023B reports LET-to-water, whereas Monte Carlo engines such as MC...

To investigate the role of interplay effects between respiratory motion and proton scanning beam interactions on free-breathing proton lattice radiotherapy (PLT) plans relative to dose distributions from static calculations.

Dose–volume metrics alone incompletely explains mandibular osteoradionecrosis (ORN) following proton therapy. LET-based aggregate approaches such as dose–LET volume histograms (DLVH) implicitly assume uniform LET contribution across dose levels. This study in...

Hypofractionated proton therapy for pancreatic cancer is limited by the proximity of radiosensitive abdominal organs. Single-energy Bragg peak (SEBP) proton delivery enables ultra-high dose-rate (UHDR) irradiation and may facilitate FLASH compatible treatment...

While 30% of lung cancer patients cannot tolerate breath-hold, free-breathing(FB) proton pencil-beam-scanning(PBS) deliveries compromise target coverage from the interplay effects of large motion. This study presents a novel FB-gated spirometer-based respirat...

To implement a full abdominal motion model that combines respiration with gastrointestinal (GI) motility and quantify its interplay impact in pencil-beam scanning (PBS) proton therapy.

Proton LATTICE radiotherapy (LRT), a spatially fractionated radiotherapy (SFRT), delivers high dose to intratumoral vertices while maintaining low valley dose. Single-field optimization (SFO) is robust in preserving peak-to-valley patterns but may increase en...

Ultra-high-dose-rate (UHDR) proton irradiation may spare normal tissue (FLASH effect), but PBS proton dose rate is limited by machine constraints (minimum MU/spot and dwell time). Intra-field interruptions can leave sub-threshold MU for remaining delivery, de...

To systematically evaluate if optimized spot-delivery patterns in pencil-beam scanning can reach FLASH-compatible dose rates (>40Gy/s) at clinically relevant fractions of 4Gy and to identify key machine and planning parameters for whole-brain irradiation (WBI...

With the number of proton centers increasing, each facing intermittent downtime or need for renovations. Developing optimal approaches to maintain uninterrupted treatment is essential to preserve clinical outcomes. This study outlines key risk factors, workfl...

Linear energy transfer (LETd) has been implicated in mandibular osteoradionecrosis (ORN) following proton therapy; however, its strong spatial coupling with dose has limited interpretation of whether LETd contributes independently to ORN risk. This study aims...

Intensity-modulated proton therapy (IMPT) plan optimization is time-intensive due to its high dimensionality and the inherent non-convexity of clinical dosimetric constraints. Conventional algorithms like projected gradient descent (PGD) often require extensi...

To quantify the impact of gastrointestinal (GI) motility on pencil-beam scanning (PBS) proton therapy for abdominal cancers, and assess how fractionation and motion amplitude mitigate motility-induced interplay effects.