Victor V. Onecha

Mechanistic models can help us understand why hadrons kill cells more effectively than photons. We used ChronoRepair, an agent-based model that tracks individual double-strand breaks (DSB) through detection, repair, and cell-fate decisions, to identify which...

Preclinical studies combining radiation with gadolinium-based AGuIX nanoparticles show potent radiosensitization effect. However, physics simulations to date show a lack of macroscopic dose enhancement. We address this by shifting from absorbed dose (D) to mi...

To develop a fast and scalable computational framework for estimating DNA damage induced by X-ray irradiation while retaining track-structure fidelity and reducing computational cost.

IM/TH- Radiopharmaceutical Therapy